Assay Detail
Functional
CHEMBL4139874
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Antiviral activity against HCV infected in human Huh7-J17 cells assessed as inhibition of viral RNA replication after 72 hrs by bright-glo luciferase reporter assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel thioglycosyl analogs of glycosyltransferase substrates as antiviral compounds against classical swine fever virus and hepatitis C virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.13 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 7.55 |
| CHEMBL4162474 | — | — | 1 | 5.43 |
| CHEMBL4173159 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1259059 | SOFOSBUVIR | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4162474 | — | IC50 | = | 3741.0 | nM | 5.43 |
| CHEMBL4173159 | — | IC50 | = | 4005.0 | nM | 5.40 |