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Assay Detail

CHEMBL4139985

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of soybean lipoxygenase using linoleic acid as substrate preincubated for 5 mins followed by substrate addition measuredf after 7 mins by solution A/B solution based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Lipoxygenase (CHEMBL1641359)
Type SINGLE PROTEIN
Organism Glycine max

Publication

Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.
Pluta K, Jeleń M, Morak-Młodawska B, Zimecki M, Artym J, Kocięba M, Zaczyńska E.
Eur J Med Chem (2017) 138 : 774 -806
PubMed 28734245 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 4.37 4.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL437540 1 4.67
CHEMBL226300 1 4.39
CHEMBL4164951 1 4.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL437540 IC50 = 21200.0 nM 4.67
CHEMBL226300 IC50 = 40700.0 nM 4.39
CHEMBL4164951 IC50 = 87700.0 nM 4.06