Assay Detail
Functional
CHEMBL4140740
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Antiparasitic activity against Leishmania major amastigotes infected in mouse RAW 264.7 cells after 96 hrs by luciferase reporter gene assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 4.94 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168740 | — | — | 1 | 6.17 |
| CHEMBL4164550 | — | — | 1 | 5.73 |
| CHEMBL4162775 | — | — | 1 | 5.30 |
| CHEMBL4171831 | — | — | 1 | 5.28 |
| CHEMBL4172435 | — | — | 1 | 5.20 |
| CHEMBL4165142 | — | — | 1 | 5.18 |
| CHEMBL3637894 | — | — | 1 | 5.09 |
| CHEMBL4163364 | — | — | 1 | 5.06 |
| CHEMBL4177159 | — | — | 1 | 4.90 |
| CHEMBL4176839 | — | — | 1 | 4.64 |
| CHEMBL4163176 | — | — | 1 | 4.62 |
| CHEMBL4166222 | — | — | 1 | 4.62 |
| CHEMBL4173481 | — | — | 1 | 4.60 |
| CHEMBL4171216 | — | — | 1 | 4.59 |
| CHEMBL4171319 | — | — | 1 | 4.59 |
| CHEMBL4160723 | — | — | 1 | 4.59 |
| CHEMBL4160939 | — | — | 1 | 4.59 |
| CHEMBL4173041 | — | — | 1 | 4.59 |
| CHEMBL4161711 | — | — | 1 | 4.59 |
| CHEMBL4176605 | — | — | 1 | - |
| CHEMBL4169642 | — | — | 1 | - |
| CHEMBL4171096 | — | — | 1 | - |
| CHEMBL4175838 | — | — | 1 | - |
| CHEMBL4171684 | — | — | 1 | - |
| CHEMBL4161076 | — | — | 1 | - |
| CHEMBL4175127 | — | — | 1 | - |
| CHEMBL4160007 | — | — | 1 | - |
| CHEMBL4159864 | — | — | 1 | - |
| CHEMBL4173238 | — | — | 1 | - |
| CHEMBL4176462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168740 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4164550 | — | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4162775 | — | EC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL4171831 | — | EC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL4172435 | — | EC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL4165142 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3637894 | — | EC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL4163364 | — | EC50 | = | 8780.0 | nM | 5.06 |
| CHEMBL4177159 | — | EC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4176839 | — | EC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL4163176 | — | EC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL4166222 | — | EC50 | = | 24130.0 | nM | 4.62 |
| CHEMBL4173481 | — | EC50 | = | 25090.0 | nM | 4.60 |
| CHEMBL4171319 | — | EC50 | = | 25950.0 | nM | 4.59 |
| CHEMBL4160723 | — | EC50 | = | 25880.0 | nM | 4.59 |
| CHEMBL4160939 | — | EC50 | = | 25950.0 | nM | 4.59 |
| CHEMBL4173041 | — | EC50 | = | 25610.0 | nM | 4.59 |
| CHEMBL4161711 | — | EC50 | = | 25680.0 | nM | 4.59 |
| CHEMBL4171216 | — | EC50 | = | 25880.0 | nM | 4.59 |
| CHEMBL4167924 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4164489 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4171268 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4166390 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4177008 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4169813 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4176462 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4173238 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4159864 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4160007 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4175127 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4161076 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4171684 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4175838 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4171096 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4169642 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4176605 | — | EC50 | > | 15000.0 | nM | - |