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Assay Detail

CHEMBL4140743

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasitic activity against Plasmodium falciparum C235 assessed as growth inhibition incubated for 5 days by SYBR Green I dye-based fluorescence assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation.
Woodring JL, Bachovchin KA, Brady KG, Gallerstein MF, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP.
Eur J Med Chem (2017) 141 : 446 -459
PubMed 29049963 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 36 5.56 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4175838 1 7.00
CHEMBL4164550 1 6.40
CHEMBL4160939 1 6.30
CHEMBL4163364 1 6.00
CHEMBL3637894 1 5.96
CHEMBL4171096 1 5.92
CHEMBL4173238 1 5.82
CHEMBL4171319 1 5.77
CHEMBL4168740 1 5.72
CHEMBL4166390 1 5.70
CHEMBL4171684 1 5.68
CHEMBL4162775 1 5.51
CHEMBL4176605 1 5.50
CHEMBL4159864 1 5.50
CHEMBL4161076 1 5.47
CHEMBL4175127 1 5.46
CHEMBL4177008 1 5.35
CHEMBL4160007 1 5.34
CHEMBL4169813 1 5.12
CHEMBL4167924 1 5.12
CHEMBL4161711 1 5.06
CHEMBL4171268 1 4.96
CHEMBL4173481 1 4.89
CHEMBL4172435 1 4.74
CHEMBL4160723 1 4.68
CHEMBL4176462 1 -
CHEMBL4169642 1 -
CHEMBL4164489 1 -
CHEMBL4171216 1 -
CHEMBL4177159 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4175838 EC50 = 100.0 nM 7.00
CHEMBL4164550 EC50 = 400.0 nM 6.40
CHEMBL4160939 EC50 = 500.0 nM 6.30
CHEMBL4163364 EC50 = 1000.0 nM 6.00
CHEMBL3637894 EC50 = 1100.0 nM 5.96
CHEMBL4171096 EC50 = 1200.0 nM 5.92
CHEMBL4173238 EC50 = 1500.0 nM 5.82
CHEMBL4171319 EC50 = 1700.0 nM 5.77
CHEMBL4168740 EC50 = 1900.0 nM 5.72
CHEMBL4166390 EC50 = 2000.0 nM 5.70
CHEMBL4171684 EC50 = 2100.0 nM 5.68
CHEMBL4162775 EC50 = 3100.0 nM 5.51
CHEMBL4176605 EC50 = 3200.0 nM 5.50
CHEMBL4159864 EC50 = 3200.0 nM 5.50
CHEMBL4161076 EC50 = 3400.0 nM 5.47
CHEMBL4175127 EC50 = 3500.0 nM 5.46
CHEMBL4177008 EC50 = 4500.0 nM 5.35
CHEMBL4160007 EC50 = 4600.0 nM 5.34
CHEMBL4169813 EC50 = 7600.0 nM 5.12
CHEMBL4167924 EC50 = 7600.0 nM 5.12
CHEMBL4161711 EC50 = 8800.0 nM 5.06
CHEMBL4171268 EC50 = 11100.0 nM 4.96
CHEMBL4173481 EC50 = 13000.0 nM 4.89
CHEMBL4172435 EC50 = 18300.0 nM 4.74
CHEMBL4160723 EC50 = 21000.0 nM 4.68
CHEMBL4163176 EC50 > 20000.0 nM -
CHEMBL4173041 EC50 > 20000.0 nM -
CHEMBL4165142 EC50 > 20000.0 nM -
CHEMBL4166222 EC50 > 20000.0 nM -
CHEMBL4176839 EC50 > 20000.0 nM -
CHEMBL4171831 EC50 > 5000.0 nM -
CHEMBL4177159 EC50 > 15000.0 nM -
CHEMBL4171216 EC50 > 20000.0 nM -
CHEMBL4164489 EC50 > 15000.0 nM -
CHEMBL4169642 EC50 > 15000.0 nM -
CHEMBL4176462 EC50 > 15000.0 nM -