Assay Detail
Functional
CHEMBL4140750
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Antiproliferative activity against human HeLa cells after 96 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.19 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.57 |
| CHEMBL4174684 | — | — | 1 | 6.19 |
| CHEMBL4163335 | — | — | 1 | 6.01 |
| CHEMBL4174066 | — | — | 1 | 5.80 |
| CHEMBL4166148 | — | — | 1 | 5.64 |
| CHEMBL4171645 | — | — | 1 | 5.48 |
| CHEMBL4170633 | — | — | 1 | 5.02 |
| CHEMBL4171238 | — | — | 1 | 4.99 |
| CHEMBL4161042 | — | — | 1 | 4.96 |
| CHEMBL4177429 | — | — | 1 | 4.88 |
| CHEMBL4167882 | — | — | 1 | 4.86 |
| CHEMBL4159962 | — | — | 1 | 4.76 |
| CHEMBL4162707 | — | — | 1 | 4.75 |
| CHEMBL4169577 | — | — | 1 | 4.65 |
| CHEMBL4175091 | — | — | 1 | 4.60 |
| CHEMBL4167247 | — | — | 1 | 4.50 |
| CHEMBL4164453 | — | — | 1 | 4.41 |
| CHEMBL4159334 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4174684 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4163335 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4174066 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4166148 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4171645 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4170633 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4171238 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4161042 | — | EC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4177429 | — | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4167882 | — | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4159962 | — | EC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL4162707 | — | EC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4169577 | — | EC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL4175091 | — | EC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4167247 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4164453 | — | EC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL4159334 | — | EC50 | = | 44100.0 | nM | 4.36 |