Assay Detail
Functional
CHEMBL4140754
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Antiproliferative activity against human A427 cells after 96 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-427 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.11 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.35 |
| CHEMBL4174684 | — | — | 1 | 5.92 |
| CHEMBL4163335 | — | — | 1 | 5.80 |
| CHEMBL4174066 | — | — | 1 | 5.55 |
| CHEMBL4166148 | — | — | 1 | 5.46 |
| CHEMBL4171645 | — | — | 1 | 5.41 |
| CHEMBL4171238 | — | — | 1 | 5.05 |
| CHEMBL4177429 | — | — | 1 | 5.00 |
| CHEMBL4170633 | — | — | 1 | 5.00 |
| CHEMBL4161042 | — | — | 1 | 4.97 |
| CHEMBL4167882 | — | — | 1 | 4.94 |
| CHEMBL4159962 | — | — | 1 | 4.76 |
| CHEMBL4162707 | — | — | 1 | 4.75 |
| CHEMBL4169577 | — | — | 1 | 4.61 |
| CHEMBL4175091 | — | — | 1 | 4.40 |
| CHEMBL4167247 | — | — | 1 | 4.38 |
| CHEMBL4164453 | — | — | 1 | 4.34 |
| CHEMBL4159334 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4174684 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4163335 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4174066 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4166148 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4171645 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4171238 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4177429 | — | EC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4170633 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4161042 | — | EC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4167882 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4159962 | — | EC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4162707 | — | EC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4169577 | — | EC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL4175091 | — | EC50 | = | 39600.0 | nM | 4.40 |
| CHEMBL4167247 | — | EC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL4164453 | — | EC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL4159334 | — | EC50 | = | 52100.0 | nM | 4.28 |