Assay Detail
Functional
CHEMBL4140756
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Antiproliferative activity against human DAN-G cells after 96 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DAN-G |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 4.51 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.23 |
| CHEMBL4174684 | — | — | 1 | 4.81 |
| CHEMBL4163335 | — | — | 1 | 4.72 |
| CHEMBL4166148 | — | — | 1 | 4.72 |
| CHEMBL4174066 | — | — | 1 | 4.70 |
| CHEMBL4171645 | — | — | 1 | 4.57 |
| CHEMBL4171238 | — | — | 1 | 4.43 |
| CHEMBL4167882 | — | — | 1 | 4.40 |
| CHEMBL4170633 | — | — | 1 | 4.38 |
| CHEMBL4177429 | — | — | 1 | 4.38 |
| CHEMBL4161042 | — | — | 1 | 4.30 |
| CHEMBL4162707 | — | — | 1 | 4.24 |
| CHEMBL4159962 | — | — | 1 | 4.11 |
| CHEMBL4169577 | — | — | 1 | 4.09 |
| CHEMBL4175091 | — | — | 1 | 4.05 |
| CHEMBL4164453 | — | — | 1 | 4.04 |
| CHEMBL4167247 | — | — | 1 | 4.04 |
| CHEMBL4159334 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4174684 | — | EC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4163335 | — | EC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4166148 | — | EC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4174066 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4171645 | — | EC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL4171238 | — | EC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL4167882 | — | EC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL4170633 | — | EC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL4177429 | — | EC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL4161042 | — | EC50 | = | 49800.0 | nM | 4.30 |
| CHEMBL4162707 | — | EC50 | = | 57200.0 | nM | 4.24 |
| CHEMBL4159962 | — | EC50 | = | 78300.0 | nM | 4.11 |
| CHEMBL4169577 | — | EC50 | = | 81500.0 | nM | 4.09 |
| CHEMBL4175091 | — | EC50 | = | 88100.0 | nM | 4.05 |
| CHEMBL4164453 | — | EC50 | = | 90600.0 | nM | 4.04 |
| CHEMBL4167247 | — | EC50 | = | 90900.0 | nM | 4.04 |
| CHEMBL4159334 | — | EC50 | = | 98800.0 | nM | 4.00 |