Assay Detail
Binding
CHEMBL4141503
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Inhibition of human recombinant full-length HDAC1 (1 to 482 residues) expressed in baculovirus using Boc-Lys(acetyl)-AMC as substrate after 30 mins by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a fluorescent probe with HDAC6 selective inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.92 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160632 | — | — | 1 | 8.28 |
| CHEMBL4176291 | — | — | 1 | 7.44 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.16 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 4.79 |
| CHEMBL4165684 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160632 | — | IC50 | = | 5.25 | nM | 8.28 |
| CHEMBL4176291 | — | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL4165684 | — | IC50 | > | 20000.0 | nM | - |