Assay Detail
Binding
CHEMBL4141645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAO-A in rat liver mitochondria using p-tyramine as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins in presence of MAO-B inhibitor deprenyl by Amplex red dye-based fluorescence assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | mitochondria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, monoamine oxidase inhibition activity and molecular docking studies of novel 4-hydroxy-N'-[benzylidene or 1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.56 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.35 |
| CHEMBL4169543 | — | — | 1 | 6.96 |
| CHEMBL1782842 | — | — | 1 | 6.92 |
| CHEMBL475017 | — | — | 1 | 6.75 |
| CHEMBL4167042 | — | — | 1 | 6.62 |
| CHEMBL4172849 | — | — | 1 | 6.50 |
| CHEMBL4176805 | — | — | 1 | 6.48 |
| CHEMBL475188 | — | — | 1 | 6.46 |
| CHEMBL4165825 | — | — | 1 | 6.42 |
| CHEMBL4164943 | — | — | 1 | 6.36 |
| CHEMBL4161683 | — | — | 1 | 6.02 |
| CHEMBL4167829 | — | — | 1 | 5.96 |
| CHEMBL4166188 | — | — | 1 | 5.91 |
| CHEMBL1782841 | — | — | 1 | 5.80 |
| CHEMBL471758 | — | — | 1 | 5.72 |
| CHEMBL4163328 | — | — | 1 | 5.53 |
| CHEMBL4161532 | — | — | 1 | 5.31 |
| CHEMBL471769 | — | — | 1 | 5.29 |
| CHEMBL4165104 | — | — | 1 | 5.29 |
| CHEMBL470744 | — | — | 1 | 5.24 |
| CHEMBL4169453 | — | — | 1 | 5.21 |
| CHEMBL4177110 | — | — | 1 | 5.18 |
| CHEMBL4169131 | — | — | 1 | 5.13 |
| CHEMBL4167325 | — | — | 1 | 5.02 |
| CHEMBL4173753 | — | — | 1 | 4.97 |
| CHEMBL1782829 | — | — | 1 | 4.95 |
| CHEMBL4167525 | — | — | 1 | 4.94 |
| CHEMBL4171408 | — | — | 1 | 4.77 |
| CHEMBL4169612 | — | — | 1 | 4.73 |
| CHEMBL4176639 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4169543 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1782842 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL475017 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4167042 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4172849 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4176805 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL475188 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4165825 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4164943 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4161683 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4167829 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4166188 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1782841 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL471758 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4163328 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL4161532 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL471769 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL4165104 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL470744 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL4169453 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL4177110 | — | IC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL4169131 | — | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL4167325 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL4173753 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL1782829 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4167525 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4171408 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL4169612 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL4176639 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4166029 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4176626 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL4173005 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL4159611 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL4162583 | — | IC50 | = | 53400.0 | nM | 4.27 |
| CHEMBL8663 | — | IC50 | = | 67250.0 | nM | 4.17 |
| CHEMBL4163586 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL4160794 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL4173275 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL1782814 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL4176387 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL4171487 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL4159508 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL4164808 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL4168526 | — | IC50 | >= | 100000.0 | nM | - |