Assay Detail
Binding
CHEMBL4141682
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Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by Ellman's method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Arylbenzofurans from Artocarpus lakoocha and methyl ether analogs with potent cholinesterase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.43 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4159281 | — | — | 1 | 6.06 |
| CHEMBL465156 | LAKOOCHIN B | — | 1 | 5.97 |
| CHEMBL4175881 | — | — | 1 | 5.96 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.84 |
| CHEMBL463296 | LAKOOCHIN A | — | 1 | 4.56 |
| CHEMBL4175343 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4159281 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL465156 | LAKOOCHIN B | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4175881 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL463296 | LAKOOCHIN A | IC50 | = | 27420.0 | nM | 4.56 |
| CHEMBL4175343 | — | IC50 | = | 61860.0 | nM | 4.21 |