Assay Detail
Binding
CHEMBL4141785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-prazosin from rat alpha1A adrenergic receptor after 60 mins by scintillation counting analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of small molecule agonists of EphA2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.70 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 9.13 |
| CHEMBL4170029 | — | — | 1 | 8.60 |
| CHEMBL4166644 | — | — | 1 | 8.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL707 | DOXAZOSIN | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL4170029 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4166644 | — | IC50 | = | 4.28 | nM | 8.37 |