Assay Detail
Functional
CHEMBL4141789
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Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
DMXAA-pyranoxanthone hybrids enhance inhibition activities against human cancer cells with multi-target functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.87 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163041 | — | — | 1 | 6.27 |
| CHEMBL4162172 | — | — | 1 | 5.06 |
| CHEMBL4172845 | — | — | 1 | 4.48 |
| CHEMBL4165603 | — | — | 1 | 4.29 |
| CHEMBL71263 | VADIMEZAN | 3.0 | 1 | 4.26 |
| CHEMBL2387036 | DIHYDRO-12-HYDROXY-2,2-DIMETHYL-2H,6H-PYRANO[3,2-B]XANTHEN-6-ONE | — | 1 | - |
| CHEMBL4171121 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163041 | — | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL4162172 | — | IC50 | = | 8723.0 | nM | 5.06 |
| CHEMBL4172845 | — | IC50 | = | 33220.0 | nM | 4.48 |
| CHEMBL4165603 | — | IC50 | = | 51740.0 | nM | 4.29 |
| CHEMBL71263 | VADIMEZAN | IC50 | = | 54410.0 | nM | 4.26 |
| CHEMBL2387036 | DIHYDRO-12-HYDROXY-2,2-DIMETHYL-2H,6H-PYRANO[3,2-B]XANTHEN-6-ONE | IC50 | = | 101500.0 | nM | - |
| CHEMBL4171121 | — | IC50 | = | 138700.0 | nM | - |