Assay Detail
Functional
CHEMBL4141907
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Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
10
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.97 | 8.03 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.03 |
| CHEMBL4177309 | — | — | 2 | 5.43 |
| CHEMBL4169458 | — | — | 1 | 5.26 |
| CHEMBL4166032 | — | — | 1 | 5.17 |
| CHEMBL486400 | HEDERAGENIN | — | 1 | - |
| CHEMBL4167113 | — | — | 1 | - |
| CHEMBL4173952 | — | — | 1 | - |
| CHEMBL4176226 | — | — | 1 | - |
| CHEMBL4165616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4177309 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4169458 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4166032 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL486400 | HEDERAGENIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL4167113 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4177309 | — | Activity | - | — | - | |
| CHEMBL4173952 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4176226 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4165616 | — | IC50 | > | 10000.0 | nM | - |