Assay Detail
Functional
CHEMBL4141909
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Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay
10
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.86 | 8.18 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.18 |
| CHEMBL4177309 | — | — | 2 | 5.44 |
| CHEMBL4169458 | — | — | 1 | 5.38 |
| CHEMBL4166032 | — | — | 1 | 5.16 |
| CHEMBL4167113 | — | — | 1 | 5.13 |
| CHEMBL486400 | HEDERAGENIN | — | 1 | - |
| CHEMBL4173952 | — | — | 1 | - |
| CHEMBL4176226 | — | — | 1 | - |
| CHEMBL4165616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4177309 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4169458 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4166032 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4167113 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL486400 | HEDERAGENIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL4177309 | — | Activity | - | — | - | |
| CHEMBL4173952 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4176226 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4165616 | — | IC50 | > | 10000.0 | nM | - |