Assay Detail
Functional
CHEMBL4141960
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Antiproliferative activity against human PANC1 cells after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PANC-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.81 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164820 | — | — | 1 | 5.10 |
| CHEMBL4167822 | — | — | 1 | 5.08 |
| CHEMBL4170805 | — | — | 1 | 4.72 |
| CHEMBL4160028 | — | — | 1 | 4.69 |
| CHEMBL4159910 | — | — | 1 | 4.68 |
| CHEMBL4165444 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164820 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4167822 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4170805 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL4160028 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL4159910 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4165444 | — | IC50 | = | 24400.0 | nM | 4.61 |