Assay Detail
Binding
CHEMBL4142230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aromatase (unknown origin) using O-benzyl fluorescein benzyl ester as substrate in presence of NADPH-generating system by fluorescence assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, molecular docking, and QSAR study of sulfonamide-based indoles as aromatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.51 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | 8.72 |
| CHEMBL4173941 | — | — | 1 | 6.16 |
| CHEMBL4161859 | — | — | 1 | 6.10 |
| CHEMBL4170504 | — | — | 1 | 5.89 |
| CHEMBL4166016 | — | — | 1 | 5.85 |
| CHEMBL4176982 | — | — | 1 | 5.77 |
| CHEMBL4174326 | — | — | 1 | 5.64 |
| CHEMBL4162572 | — | — | 1 | 5.64 |
| CHEMBL4173619 | — | — | 1 | 5.60 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.58 |
| CHEMBL4171198 | — | — | 1 | 5.57 |
| CHEMBL4174637 | — | — | 1 | 5.57 |
| CHEMBL4159550 | — | — | 1 | 5.55 |
| CHEMBL4172837 | — | — | 1 | 5.55 |
| CHEMBL4163649 | — | — | 1 | 5.50 |
| CHEMBL4160591 | — | — | 1 | 5.47 |
| CHEMBL4165064 | — | — | 1 | 5.46 |
| CHEMBL4163983 | — | — | 1 | 5.46 |
| CHEMBL4159184 | — | — | 1 | 5.42 |
| CHEMBL4170175 | — | — | 1 | 5.41 |
| CHEMBL4159524 | — | — | 1 | 5.40 |
| CHEMBL4162163 | — | — | 1 | 5.39 |
| CHEMBL4169784 | — | — | 1 | 5.38 |
| CHEMBL4167098 | — | — | 1 | 5.36 |
| CHEMBL4166364 | — | — | 1 | 5.34 |
| CHEMBL4159101 | — | — | 1 | 5.27 |
| CHEMBL4167430 | — | — | 1 | 5.26 |
| CHEMBL4169756 | — | — | 1 | 5.12 |
| CHEMBL4166769 | — | — | 1 | 5.08 |
| CHEMBL4162907 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1444 | LETROZOLE | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4173941 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4161859 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4170504 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4166016 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4176982 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4174326 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4162572 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4173619 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4171198 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4174637 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4159550 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4172837 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4163649 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4160591 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4165064 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4163983 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4159184 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4170175 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4159524 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4162163 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4169784 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4167098 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4166364 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4159101 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4167430 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4169756 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4166769 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4162907 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4168266 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4167841 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4172955 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4170393 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4174670 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4175698 | — | IC50 | = | 15300.0 | nM | 4.82 |