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Assay Detail

CHEMBL4142231

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against GFP-expressing African green monkey Vero cells after 4 days by fluorescence assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Chlorocebus sabaeus
Cell Type Vero
Confidence 1 — Organism
Curated By Intermediate

Target

Vero (CHEMBL391)
Type CELL-LINE
Organism Chlorocebus sabaeus

Publication

Synthesis, molecular docking, and QSAR study of sulfonamide-based indoles as aromatase inhibitors.
Pingaew R, Mandi P, Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V.
Eur J Med Chem (2018) 143 : 1604 -1615
PubMed 29137864 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 4.85 5.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123 ELLIPTECINE 1 5.71
CHEMBL4170504 1 4.88
CHEMBL4162163 1 4.83
CHEMBL4167098 1 4.82
CHEMBL4166016 1 4.82
CHEMBL4163649 1 4.79
CHEMBL4160591 1 4.61
CHEMBL4171198 1 4.35
CHEMBL4170393 1 -
CHEMBL4162907 1 -
CHEMBL4159184 1 -
CHEMBL4174326 1 -
CHEMBL4162572 1 -
CHEMBL4172837 1 -
CHEMBL4161859 1 -
CHEMBL4169784 1 -
CHEMBL4176982 1 -
CHEMBL4166364 1 -
CHEMBL4173619 1 -
CHEMBL4172955 1 -
CHEMBL4165064 1 -
CHEMBL4174637 1 -
CHEMBL4163983 1 -
CHEMBL4159101 1 -
CHEMBL4159524 1 -
CHEMBL4169756 1 -
CHEMBL4167430 1 -
CHEMBL4173941 1 -
CHEMBL4175698 1 -
CHEMBL4167841 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123 ELLIPTECINE IC50 = 1940.0 nM 5.71
CHEMBL4170504 IC50 = 13330.0 nM 4.88
CHEMBL4162163 IC50 = 14760.0 nM 4.83
CHEMBL4167098 IC50 = 15060.0 nM 4.82
CHEMBL4166016 IC50 = 14980.0 nM 4.82
CHEMBL4163649 IC50 = 16180.0 nM 4.79
CHEMBL4160591 IC50 = 24810.0 nM 4.61
CHEMBL4171198 IC50 = 44860.0 nM 4.35
CHEMBL4162572 IC50 > 50.0 ug.mL-1 -
CHEMBL4168266 IC50 > 50.0 ug.mL-1 -
CHEMBL4172837 IC50 > 50.0 ug.mL-1 -
CHEMBL4161859 IC50 > 50.0 ug.mL-1 -
CHEMBL4169784 IC50 > 50.0 ug.mL-1 -
CHEMBL4176982 IC50 > 50.0 ug.mL-1 -
CHEMBL4166364 IC50 > 50.0 ug.mL-1 -
CHEMBL4173619 IC50 > 50.0 ug.mL-1 -
CHEMBL4162907 IC50 > 50.0 ug.mL-1 -
CHEMBL4170175 IC50 > 50.0 ug.mL-1 -
CHEMBL4159550 IC50 > 50.0 ug.mL-1 -
CHEMBL4166769 IC50 > 50.0 ug.mL-1 -
CHEMBL4174670 IC50 > 50.0 ug.mL-1 -
CHEMBL4174326 IC50 > 50.0 ug.mL-1 -
CHEMBL4159184 IC50 > 50.0 ug.mL-1 -
CHEMBL4170393 IC50 > 50.0 ug.mL-1 -
CHEMBL4172955 IC50 > 50.0 ug.mL-1 -
CHEMBL4165064 IC50 > 50.0 ug.mL-1 -
CHEMBL4174637 IC50 > 50.0 ug.mL-1 -
CHEMBL4163983 IC50 > 50.0 ug.mL-1 -
CHEMBL4159101 IC50 > 50.0 ug.mL-1 -
CHEMBL4159524 IC50 > 50.0 ug.mL-1 -
CHEMBL4169756 IC50 > 50.0 ug.mL-1 -
CHEMBL4167430 IC50 > 50.0 ug.mL-1 -
CHEMBL4173941 IC50 > 50.0 ug.mL-1 -
CHEMBL4175698 IC50 > 50.0 ug.mL-1 -
CHEMBL4167841 IC50 > 50.0 ug.mL-1 -