Assay Detail
Functional
CHEMBL4142237
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Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.43 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.40 |
| CHEMBL1320139 | HELIOMYCIN | 2.0 | 1 | 6.16 |
| CHEMBL4176203 | — | — | 1 | 6.10 |
| CHEMBL4167935 | — | — | 1 | 6.10 |
| CHEMBL4164500 | — | — | 1 | 5.72 |
| CHEMBL4162147 | — | — | 1 | 5.64 |
| CHEMBL4172378 | — | — | 1 | 5.54 |
| CHEMBL4165587 | — | — | 1 | 5.52 |
| CHEMBL4167223 | — | — | 1 | 5.47 |
| CHEMBL4159315 | — | — | 1 | 5.47 |
| CHEMBL4176332 | — | — | 1 | 5.46 |
| CHEMBL4169013 | — | — | 1 | 5.42 |
| CHEMBL4172822 | — | — | 1 | 5.38 |
| CHEMBL4161088 | — | — | 1 | 5.06 |
| CHEMBL4174443 | — | — | 1 | 4.85 |
| CHEMBL4166135 | — | — | 1 | 4.77 |
| CHEMBL4175791 | — | — | 1 | 4.51 |
| CHEMBL4165717 | — | — | 1 | 4.21 |
| CHEMBL4163772 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1320139 | HELIOMYCIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4176203 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4167935 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4164500 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4162147 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4172378 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4165587 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4167223 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4159315 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4176332 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4169013 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4172822 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4161088 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4174443 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4166135 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4175791 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4165717 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL4163772 | — | IC50 | > | 250000.0 | nM | - |