Assay Detail
ADMET
CHEMBL4142241
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Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HMEC-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.12 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1320139 | HELIOMYCIN | 2.0 | 1 | 6.30 |
| CHEMBL4176332 | — | — | 1 | 5.23 |
| CHEMBL4161088 | — | — | 1 | 5.11 |
| CHEMBL4166135 | — | — | 1 | 4.49 |
| CHEMBL4175791 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1320139 | HELIOMYCIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4176332 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4161088 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4166135 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL4175791 | — | IC50 | = | 34300.0 | nM | 4.46 |