Assay Detail
Binding
CHEMBL4142928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition measured after 20 mins by spectrophotometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.78 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.19 |
| CHEMBL4163970 | — | — | 1 | 6.08 |
| CHEMBL4173408 | — | — | 1 | 6.00 |
| CHEMBL4162100 | — | — | 1 | 5.96 |
| CHEMBL4159445 | — | — | 1 | 5.21 |
| CHEMBL4167349 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4163970 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4173408 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4162100 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4159445 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4167349 | — | IC50 | = | 6200.0 | nM | 5.21 |