Assay Detail
Binding
CHEMBL4142947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.47 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161127 | — | — | 1 | 7.77 |
| CHEMBL1479277 | — | — | 1 | 7.69 |
| CHEMBL4162187 | — | — | 1 | 7.67 |
| CHEMBL2273029 | — | — | 1 | 7.64 |
| CHEMBL4172760 | — | — | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | 7.60 |
| CHEMBL4173179 | — | — | 1 | 7.56 |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | — | 1 | 7.52 |
| CHEMBL4171890 | — | — | 1 | 7.52 |
| CHEMBL4164851 | — | — | 1 | 7.51 |
| CHEMBL4175605 | — | — | 1 | 7.51 |
| CHEMBL4160716 | — | — | 1 | 7.51 |
| CHEMBL4171312 | — | — | 1 | 7.50 |
| CHEMBL1819437 | — | — | 1 | 7.50 |
| CHEMBL4172425 | — | — | 1 | 7.45 |
| CHEMBL4176549 | — | — | 1 | 7.45 |
| CHEMBL4162493 | — | — | 1 | 7.44 |
| CHEMBL244743 | ESCULETIN | — | 1 | 7.44 |
| CHEMBL4161438 | — | — | 1 | 7.43 |
| CHEMBL3262900 | — | — | 1 | 7.42 |
| CHEMBL4169362 | — | — | 1 | 7.42 |
| CHEMBL1372308 | — | — | 1 | 7.40 |
| CHEMBL487711 | 7-ACETOXYCOUMARIN | — | 1 | 7.40 |
| CHEMBL325841 | — | — | 1 | 7.33 |
| CHEMBL1538522 | — | — | 1 | 7.29 |
| CHEMBL4165930 | — | — | 1 | 7.02 |
| CHEMBL3262899 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161127 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1479277 | — | Ki | = | 20.3 | nM | 7.69 |
| CHEMBL4162187 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL2273029 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL4172760 | — | Ki | = | 24.2 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL51628 | UMBELLIFERONE | Ki | = | 24.9 | nM | 7.60 |
| CHEMBL4173179 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL4171890 | — | Ki | = | 29.9 | nM | 7.52 |
| CHEMBL4164851 | — | Ki | = | 30.9 | nM | 7.51 |
| CHEMBL4175605 | — | Ki | = | 30.8 | nM | 7.51 |
| CHEMBL4160716 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL4171312 | — | Ki | = | 31.5 | nM | 7.50 |
| CHEMBL1819437 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL4172425 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL4176549 | — | Ki | = | 35.3 | nM | 7.45 |
| CHEMBL4162493 | — | Ki | = | 36.6 | nM | 7.44 |
| CHEMBL244743 | ESCULETIN | Ki | = | 36.4 | nM | 7.44 |
| CHEMBL4161438 | — | Ki | = | 37.4 | nM | 7.43 |
| CHEMBL3262900 | — | Ki | = | 38.4 | nM | 7.42 |
| CHEMBL4169362 | — | Ki | = | 38.2 | nM | 7.42 |
| CHEMBL1372308 | — | Ki | = | 39.5 | nM | 7.40 |
| CHEMBL487711 | 7-ACETOXYCOUMARIN | Ki | = | 40.2 | nM | 7.40 |
| CHEMBL325841 | — | Ki | = | 47.2 | nM | 7.33 |
| CHEMBL1538522 | — | Ki | = | 51.4 | nM | 7.29 |
| CHEMBL4165930 | — | Ki | = | 95.9 | nM | 7.02 |
| CHEMBL3262899 | — | Ki | = | 116.2 | nM | 6.93 |