Assay Detail
Binding
CHEMBL4142948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.44 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172760 | — | — | 1 | 8.26 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL1479277 | — | — | 1 | 8.19 |
| CHEMBL4160716 | — | — | 1 | 8.12 |
| CHEMBL4162187 | — | — | 1 | 8.11 |
| CHEMBL4161127 | — | — | 1 | 8.11 |
| CHEMBL4175605 | — | — | 1 | 8.11 |
| CHEMBL1819437 | — | — | 1 | 8.10 |
| CHEMBL4165930 | — | — | 1 | 8.05 |
| CHEMBL4171312 | — | — | 1 | 8.05 |
| CHEMBL244743 | ESCULETIN | — | 1 | 8.03 |
| CHEMBL4164851 | — | — | 1 | 8.03 |
| CHEMBL4173179 | — | — | 1 | 7.51 |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | — | 1 | 7.47 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | 7.35 |
| CHEMBL4169362 | — | — | 1 | 7.35 |
| CHEMBL2273029 | — | — | 1 | 7.33 |
| CHEMBL3262899 | — | — | 1 | 7.32 |
| CHEMBL4172425 | — | — | 1 | 7.19 |
| CHEMBL4171890 | — | — | 1 | 7.06 |
| CHEMBL4161438 | — | — | 1 | 7.05 |
| CHEMBL325841 | — | — | 1 | 7.04 |
| CHEMBL4176549 | — | — | 1 | 6.53 |
| CHEMBL3262900 | — | — | 1 | 6.53 |
| CHEMBL4162493 | — | — | 1 | 6.43 |
| CHEMBL1372308 | — | — | 1 | 6.40 |
| CHEMBL487711 | 7-ACETOXYCOUMARIN | — | 1 | 6.24 |
| CHEMBL1538522 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172760 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL1479277 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL4160716 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL4162187 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL4161127 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL4175605 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL1819437 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4165930 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4171312 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL244743 | ESCULETIN | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL4164851 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL4173179 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL51628 | UMBELLIFERONE | Ki | = | 45.1 | nM | 7.35 |
| CHEMBL4169362 | — | Ki | = | 44.9 | nM | 7.35 |
| CHEMBL2273029 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL3262899 | — | Ki | = | 48.2 | nM | 7.32 |
| CHEMBL4172425 | — | Ki | = | 64.7 | nM | 7.19 |
| CHEMBL4171890 | — | Ki | = | 87.4 | nM | 7.06 |
| CHEMBL4161438 | — | Ki | = | 89.1 | nM | 7.05 |
| CHEMBL325841 | — | Ki | = | 90.8 | nM | 7.04 |
| CHEMBL4176549 | — | Ki | = | 293.7 | nM | 6.53 |
| CHEMBL3262900 | — | Ki | = | 292.4 | nM | 6.53 |
| CHEMBL4162493 | — | Ki | = | 369.2 | nM | 6.43 |
| CHEMBL1372308 | — | Ki | = | 402.2 | nM | 6.40 |
| CHEMBL487711 | 7-ACETOXYCOUMARIN | Ki | = | 573.2 | nM | 6.24 |
| CHEMBL1538522 | — | Ki | = | 814.4 | nM | 6.09 |