Assay Detail
Functional
CHEMBL4143256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562R cells after 72 hrs by resazurin-based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K-562R |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.03 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4159373 | — | — | 1 | 10.00 |
| CHEMBL4172942 | — | — | 1 | 9.82 |
| CHEMBL508617 | — | — | 1 | 9.70 |
| CHEMBL4162270 | — | — | 1 | 8.70 |
| CHEMBL4166186 | — | — | 1 | 8.70 |
| CHEMBL498271 | — | — | 1 | 8.66 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4159373 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4172942 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL508617 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4162270 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4166186 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL498271 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 23.0 | nM | 7.64 |