Assay Detail
Functional
CHEMBL4143277
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Antiproliferative activity against human COLO205 cells after 72 hrs by Alamarblue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.63 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165119 | — | — | 1 | 5.65 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 5.61 |
| CHEMBL4170972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165119 | — | IC50 | = | 2242.0 | nM | 5.65 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 2449.0 | nM | 5.61 |
| CHEMBL4170972 | — | IC50 | - | — | - |