Assay Detail
Binding
CHEMBL4143387
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Inhibition of human SGLT2 expressed in CHO cells assessed as reduction in [14C]AMG uptake after 1 hr by microbeta counting method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 6.69 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 8.70 |
| CHEMBL4164934 | — | — | 1 | 7.42 |
| CHEMBL4176765 | — | — | 1 | 7.34 |
| CHEMBL4173627 | — | — | 1 | 7.20 |
| CHEMBL4168847 | — | — | 1 | 7.19 |
| CHEMBL245067 | PHLORIZIN | — | 1 | 7.10 |
| CHEMBL4172842 | — | — | 1 | 7.06 |
| CHEMBL4166140 | — | — | 1 | 7.04 |
| CHEMBL4169906 | — | — | 1 | 7.02 |
| CHEMBL4161587 | — | — | 1 | 6.89 |
| CHEMBL4176991 | — | — | 1 | 6.82 |
| CHEMBL4165421 | — | — | 1 | 6.76 |
| CHEMBL4176700 | — | — | 1 | 6.76 |
| CHEMBL4160788 | — | — | 1 | 6.71 |
| CHEMBL4165004 | — | — | 1 | 6.69 |
| CHEMBL4165713 | — | — | 1 | 6.68 |
| CHEMBL4173333 | — | — | 1 | 6.68 |
| CHEMBL4161979 | — | — | 1 | 6.52 |
| CHEMBL4171400 | — | — | 1 | 6.47 |
| CHEMBL4170248 | — | — | 1 | 6.43 |
| CHEMBL4171709 | — | — | 1 | 6.40 |
| CHEMBL4172198 | — | — | 1 | 6.40 |
| CHEMBL4161107 | — | — | 1 | 6.37 |
| CHEMBL4175624 | — | — | 1 | 6.37 |
| CHEMBL4159626 | — | — | 1 | 6.34 |
| CHEMBL4164519 | — | — | 1 | 6.17 |
| CHEMBL4176218 | — | — | 1 | 5.71 |
| CHEMBL4168361 | — | — | 1 | 5.65 |
| CHEMBL4175153 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429910 | DAPAGLIFLOZIN | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4164934 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4176765 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4173627 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4168847 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL245067 | PHLORIZIN | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4172842 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4166140 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4169906 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4161587 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4176991 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4165421 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4176700 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4160788 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL4165004 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL4165713 | — | EC50 | = | 211.0 | nM | 6.68 |
| CHEMBL4173333 | — | EC50 | = | 208.0 | nM | 6.68 |
| CHEMBL4161979 | — | EC50 | = | 301.0 | nM | 6.52 |
| CHEMBL4171400 | — | EC50 | = | 335.0 | nM | 6.47 |
| CHEMBL4170248 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4171709 | — | EC50 | = | 396.0 | nM | 6.40 |
| CHEMBL4172198 | — | EC50 | = | 395.0 | nM | 6.40 |
| CHEMBL4161107 | — | EC50 | = | 431.0 | nM | 6.37 |
| CHEMBL4175624 | — | EC50 | = | 429.0 | nM | 6.37 |
| CHEMBL4159626 | — | EC50 | = | 457.0 | nM | 6.34 |
| CHEMBL4164519 | — | EC50 | = | 678.0 | nM | 6.17 |
| CHEMBL4176218 | — | EC50 | = | 1953.0 | nM | 5.71 |
| CHEMBL4168361 | — | EC50 | = | 2251.0 | nM | 5.65 |
| CHEMBL4175153 | — | EC50 | = | 8541.0 | nM | 5.07 |