Assay Detail
Binding
CHEMBL4143590
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear factor erythroid 2-related factor 2 (CHEMBL1075094) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.09 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521819 | — | — | 1 | 5.88 |
| CHEMBL477053 | — | — | 1 | 5.48 |
| CHEMBL559673 | — | — | 1 | 5.48 |
| CHEMBL2316157 | — | — | 1 | 5.28 |
| CHEMBL4172072 | — | — | 1 | 5.14 |
| CHEMBL4167461 | — | — | 1 | 5.14 |
| CHEMBL3105277 | — | — | 1 | 5.12 |
| CHEMBL2009362 | — | — | 1 | 5.10 |
| CHEMBL128729 | — | — | 1 | 5.00 |
| CHEMBL477052 | — | — | 1 | 4.99 |
| CHEMBL3780720 | — | — | 1 | 4.84 |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | — | 1 | 4.78 |
| CHEMBL562131 | — | — | 1 | 4.74 |
| CHEMBL4162563 | — | — | 1 | 4.68 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521819 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL477053 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL559673 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2316157 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4172072 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4167461 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3105277 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2009362 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL128729 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL477052 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3780720 | — | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | EC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL562131 | — | EC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4162563 | — | EC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL140 | CURCUMIN | EC50 | = | 21000.0 | nM | 4.68 |