Assay Detail
Functional
CHEMBL4143595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.88 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.03 |
| CHEMBL1950461 | — | — | 1 | 6.55 |
| CHEMBL1950467 | — | — | 1 | 6.54 |
| CHEMBL1950460 | — | — | 1 | 6.43 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.38 |
| CHEMBL1950478 | — | — | 1 | 6.37 |
| CHEMBL1950477 | — | — | 1 | 6.36 |
| CHEMBL1950475 | — | — | 1 | 6.33 |
| CHEMBL1950476 | — | — | 1 | 6.31 |
| CHEMBL1950465 | — | — | 1 | 6.17 |
| CHEMBL3086341 | — | — | 1 | 5.99 |
| CHEMBL1950479 | — | — | 1 | 5.98 |
| CHEMBL4168020 | — | — | 1 | 5.86 |
| CHEMBL1950466 | — | — | 1 | 5.84 |
| CHEMBL1950464 | — | — | 1 | 5.77 |
| CHEMBL4173686 | — | — | 1 | 5.73 |
| CHEMBL1950474 | — | — | 1 | 5.73 |
| CHEMBL197209 | — | — | 1 | 5.68 |
| CHEMBL277864 | — | — | 1 | 5.60 |
| CHEMBL1950459 | — | — | 1 | 5.58 |
| CHEMBL4159683 | — | — | 1 | 5.54 |
| CHEMBL280180 | — | — | 1 | 5.51 |
| CHEMBL1950463 | — | — | 1 | 5.47 |
| CHEMBL1950469 | — | — | 1 | 5.46 |
| CHEMBL1950468 | — | — | 1 | 5.39 |
| CHEMBL1950462 | — | — | 1 | 5.27 |
| CHEMBL1950473 | — | — | 1 | 5.26 |
| CHEMBL23440 | — | — | 1 | 5.17 |
| CHEMBL4166470 | — | — | 1 | 5.10 |
| CHEMBL4160096 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL1950461 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1950467 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1950460 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL1950478 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1950477 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1950475 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1950476 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1950465 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3086341 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL1950479 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4168020 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL1950466 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL1950464 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4173686 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL1950474 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL197209 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL277864 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL1950459 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL4159683 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL280180 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL1950463 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL1950469 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1950468 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL1950462 | — | IC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL1950473 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL23440 | — | IC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL4166470 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1950472 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL1950470 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL1950471 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4173354 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4165439 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4160857 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4168792 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4164258 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4172141 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4167705 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4175575 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4171073 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL4160096 | — | IC50 | > | 8000.0 | nM | - |