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Assay Detail

CHEMBL4143827

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Functional
Antichlamydial activity against Chlamydia trachomatis serovar L2 454/Bu infected in human HeLa 299 cells assessed as reduction in number of inclusion bodies measured after 44 to 48 hrs by DAPI staining-based HCS assay
ChEMBL ↗
40
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Chlamydia trachomatis
Confidence 1 — Organism
Curated By Intermediate

Target

Chlamydia trachomatis (CHEMBL614606) ↗
Type ORGANISM
Organism Chlamydia trachomatis

Publication

Natural product inspired library synthesis - Identification of 2,3-diarylbenzofuran and 2,3-dihydrobenzofuran based inhibitors of Chlamydia trachomatis.
Saleeb M, Mojica S, Eriksson AU, Andersson CD, Gylfe Å, Elofsson M.
Eur J Med Chem (2018) 143 : 1077 -1089
PubMed 29232584 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 4.96 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4162933 — — 2 6.00
CHEMBL4163605 — — 2 5.70
CHEMBL4167052 — — 2 5.62
CHEMBL4164717 — — 2 5.57
CHEMBL4174305 — — 2 5.38
CHEMBL4174933 — — 2 5.06
CHEMBL4170870 — — 2 4.97
CHEMBL4160245 — — 2 4.94
CHEMBL4171079 — — 2 4.89
CHEMBL4171500 — — 2 4.82
CHEMBL4161302 — — 2 4.82
CHEMBL4169810 — — 2 4.70
CHEMBL4168158 — — 2 4.66
CHEMBL4159571 — — 2 4.63
CHEMBL4166387 — — 2 4.60
CHEMBL4167483 — — 2 4.60
CHEMBL4159162 — — 2 4.59
CHEMBL4160641 — — 2 4.59
CHEMBL4171899 — — 2 4.57
CHEMBL4171247 — — 2 4.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4162933 — IC50 = 1000.0 nM 6.00
CHEMBL4162933 — IC50 = 997.7 nM 6.00
CHEMBL4163605 — IC50 = 2000.0 nM 5.70
CHEMBL4163605 — IC50 = 2041.74 nM 5.69
CHEMBL4167052 — IC50 = 2400.0 nM 5.62
CHEMBL4167052 — IC50 = 2443.43 nM 5.61
CHEMBL4164717 — IC50 = 2700.0 nM 5.57
CHEMBL4164717 — IC50 = 2728.98 nM 5.56
CHEMBL4174305 — IC50 = 4200.0 nM 5.38
CHEMBL4174305 — IC50 = 4207.27 nM 5.38
CHEMBL4174933 — IC50 = 8700.0 nM 5.06
CHEMBL4174933 — IC50 = 8729.71 nM 5.06
CHEMBL4170870 — IC50 = 10600.0 nM 4.97
CHEMBL4170870 — IC50 = 10616.96 nM 4.97
CHEMBL4160245 — IC50 = 11561.12 nM 4.94
CHEMBL4160245 — IC50 = 11600.0 nM 4.94
CHEMBL4171079 — IC50 = 12823.31 nM 4.89
CHEMBL4171079 — IC50 = 12800.0 nM 4.89
CHEMBL4161302 — IC50 = 15170.5 nM 4.82
CHEMBL4171500 — IC50 = 14996.85 nM 4.82
CHEMBL4171500 — IC50 = 15000.0 nM 4.82
CHEMBL4161302 — IC50 = 15200.0 nM 4.82
CHEMBL4169810 — IC50 = 19860.95 nM 4.70
CHEMBL4169810 — IC50 = 19800.0 nM 4.70
CHEMBL4168158 — IC50 = 22130.95 nM 4.66
CHEMBL4168158 — IC50 = 22100.0 nM 4.66
CHEMBL4159571 — IC50 = 23388.37 nM 4.63
CHEMBL4159571 — IC50 = 23400.0 nM 4.63
CHEMBL4167483 — IC50 = 24900.0 nM 4.60
CHEMBL4167483 — IC50 = 24888.57 nM 4.60
CHEMBL4166387 — IC50 = 25000.0 nM 4.60
CHEMBL4166387 — IC50 = 25003.45 nM 4.60
CHEMBL4160641 — IC50 = 25409.73 nM 4.59
CHEMBL4159162 — IC50 = 25800.0 nM 4.59
CHEMBL4160641 — IC50 = 25400.0 nM 4.59
CHEMBL4159162 — IC50 = 25763.21 nM 4.59
CHEMBL4171899 — IC50 = 27000.0 nM 4.57
CHEMBL4171247 — IC50 = 27200.0 nM 4.57
CHEMBL4171899 — IC50 = 27039.58 nM 4.57
CHEMBL4171247 — IC50 = 27164.39 nM 4.57