Assay Detail
Functional
CHEMBL4143828
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Antichlamydial activity against Chlamydia trachomatis serovar L2 infected in human HeLa 299 cells assessed as reduction in number of inclusion bodies measured after 44 to 48 hrs by DAPI staining-based HCS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chlamydia trachomatis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Natural product inspired library synthesis - Identification of 2,3-diarylbenzofuran and 2,3-dihydrobenzofuran based inhibitors of Chlamydia trachomatis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.95 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4162933 | — | — | 1 | 6.24 |
| CHEMBL4 | OFLOXACIN | 4.0 | 1 | 6.18 |
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 6.14 |
| CHEMBL4163605 | — | — | 1 | 6.01 |
| CHEMBL4167052 | — | — | 1 | 6.00 |
| CHEMBL4164717 | — | — | 1 | 5.74 |
| CHEMBL4174305 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4162933 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL4 | OFLOXACIN | IC50 | = | 666.0 | nM | 6.18 |
| CHEMBL529 | AZITHROMYCIN | IC50 | = | 727.0 | nM | 6.14 |
| CHEMBL4163605 | — | IC50 | = | 965.0 | nM | 6.01 |
| CHEMBL4167052 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4164717 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4174305 | — | IC50 | = | 4730.0 | nM | 5.33 |