Assay Detail
Functional
CHEMBL4144044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human RPMI8226 cells after 72 hrs by Cell-TiterGlo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.36 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2132936 | — | — | 1 | 6.59 |
| CHEMBL4177080 | — | — | 1 | 6.30 |
| CHEMBL4168815 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2132936 | — | EC50 | = | 258.0 | nM | 6.59 |
| CHEMBL4177080 | — | EC50 | = | 495.0 | nM | 6.30 |
| CHEMBL4168815 | — | EC50 | = | 631.0 | nM | 6.20 |