Assay Detail
Functional
CHEMBL4144048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HEL 92.1.7 cells after 72 hrs by Cell-TiterGlo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL 92.1.7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.43 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2132936 | — | — | 1 | 6.75 |
| CHEMBL4168815 | — | — | 1 | 6.40 |
| CHEMBL4177080 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2132936 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4168815 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4177080 | — | EC50 | = | 720.0 | nM | 6.14 |