Assay Detail
Binding
CHEMBL4144352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAMPT (unknown origin) using NAM as substrate incubated for 5 mins followed by substrate addition measured after 15 mins by fluorometric method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.59 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171570 | — | — | 1 | 8.15 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 8.05 |
| CHEMBL4162202 | — | — | 1 | 7.85 |
| CHEMBL4159972 | — | — | 1 | 7.85 |
| CHEMBL4170617 | — | — | 1 | 7.82 |
| CHEMBL4170109 | — | — | 1 | 7.75 |
| CHEMBL4163681 | — | — | 1 | 7.72 |
| CHEMBL4163345 | — | — | 1 | 7.70 |
| CHEMBL4166793 | — | — | 1 | 6.66 |
| CHEMBL4174058 | — | — | 1 | 6.33 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171570 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4162202 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4159972 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4170617 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4170109 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4163681 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4163345 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4166793 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4174058 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - |