Assay Detail
Binding
CHEMBL4144353
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Inhibition of recombinant full length human C-terminal His/flag-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells after 30 mins by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.41 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170617 | — | — | 1 | 8.70 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.58 |
| CHEMBL4163681 | — | — | 1 | 7.44 |
| CHEMBL4166793 | — | — | 1 | 7.44 |
| CHEMBL4170109 | — | — | 1 | 7.36 |
| CHEMBL4162202 | — | — | 1 | 7.34 |
| CHEMBL4163345 | — | — | 1 | 7.22 |
| CHEMBL4159972 | — | — | 1 | 7.04 |
| CHEMBL4174058 | — | — | 1 | 7.02 |
| CHEMBL4171570 | — | — | 1 | 7.00 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170617 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4163681 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4166793 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4170109 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4162202 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4163345 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4159972 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4174058 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4171570 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL566757 | DAPORINAD | IC50 | - | — | - |