Assay Detail
Functional
CHEMBL4144355
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Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.05 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4159972 | — | — | 1 | 5.57 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 5.43 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.36 |
| CHEMBL4170617 | — | — | 1 | 5.28 |
| CHEMBL4170109 | — | — | 1 | 5.18 |
| CHEMBL4162202 | — | — | 1 | 5.14 |
| CHEMBL4163681 | — | — | 1 | 5.01 |
| CHEMBL4163345 | — | — | 1 | 4.89 |
| CHEMBL4166793 | — | — | 1 | 4.72 |
| CHEMBL4174058 | — | — | 1 | 4.66 |
| CHEMBL4171570 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4159972 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4170617 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4170109 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4162202 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4163681 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4163345 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4166793 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4174058 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4171570 | — | IC50 | = | 54000.0 | nM | 4.27 |