Assay Detail
Functional
CHEMBL4144356
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Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.88 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 6.05 |
| CHEMBL4166793 | — | — | 1 | 5.16 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.04 |
| CHEMBL4163681 | — | — | 1 | 5.03 |
| CHEMBL4159972 | — | — | 1 | 4.89 |
| CHEMBL4174058 | — | — | 1 | 4.85 |
| CHEMBL4170617 | — | — | 1 | 4.62 |
| CHEMBL4170109 | — | — | 1 | 4.58 |
| CHEMBL4171570 | — | — | 1 | 4.52 |
| CHEMBL4162202 | — | — | 1 | 4.10 |
| CHEMBL4163345 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4166793 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4163681 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4159972 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4174058 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4170617 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4170109 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4171570 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4162202 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL4163345 | — | IC50 | = | 106000.0 | nM | - |