Assay Detail
Functional
CHEMBL4144599
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Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Probing the Antiallergic and Anti-inflammatory Activity of Biflavonoids and Dihydroflavonols from Dietes bicolor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.98 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63677 | ROBUSTAFLAVONE | — | 1 | 6.35 |
| CHEMBL63354 | AMENTOFLAVONE | — | 1 | 6.12 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.46 |
| CHEMBL4173249 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63677 | ROBUSTAFLAVONE | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL63354 | AMENTOFLAVONE | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL98350 | LY-294002 | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL4173249 | — | IC50 | > | 10000.0 | nM | - |