Assay Detail
Binding
CHEMBL4144832
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Inhibition of human LeuRS assessed as reduction in ATP consumption
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.18 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4174152 | — | — | 1 | 7.48 |
| CHEMBL4163450 | — | — | 1 | 6.80 |
| CHEMBL4171458 | — | — | 1 | 6.66 |
| CHEMBL4172643 | — | — | 1 | 6.31 |
| CHEMBL4159778 | — | — | 1 | 6.07 |
| CHEMBL4160841 | — | — | 1 | 5.96 |
| CHEMBL4163140 | — | — | 1 | 5.92 |
| CHEMBL4167692 | — | — | 1 | 5.70 |
| CHEMBL4171058 | — | — | 1 | 5.47 |
| CHEMBL4161986 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4174152 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4163450 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4171458 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4172643 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4159778 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4160841 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4163140 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4167692 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4171058 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4161986 | — | IC50 | = | 3900.0 | nM | 5.41 |