Assay Detail
Functional
CHEMBL4144879
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Cytotoxicity against human Pfeiffer cells assessed as decrease in cell viability after 5 days by CellTiter-Glo reagent based luminescence assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Pfeiffer |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.42 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161444 | — | — | 1 | 8.70 |
| CHEMBL4176554 | — | — | 1 | 8.52 |
| CHEMBL4162499 | — | — | 1 | 8.22 |
| CHEMBL4169762 | — | — | 1 | 8.15 |
| CHEMBL4159112 | — | — | 1 | 8.10 |
| CHEMBL4165937 | — | — | 1 | 7.96 |
| CHEMBL4169368 | — | — | 1 | 7.85 |
| CHEMBL4170327 | — | — | 1 | 7.85 |
| CHEMBL4162316 | — | — | 1 | 7.82 |
| CHEMBL4164687 | — | — | 1 | 7.77 |
| CHEMBL4172576 | — | — | 1 | 7.77 |
| CHEMBL4170753 | — | — | 1 | 7.70 |
| CHEMBL4177454 | — | — | 1 | 7.68 |
| CHEMBL4161265 | — | — | 1 | 7.68 |
| CHEMBL3414621 | TAZEMETOSTAT | 4.0 | 1 | 7.42 |
| CHEMBL4176373 | — | — | 1 | 6.82 |
| CHEMBL4169191 | — | — | 1 | 6.80 |
| CHEMBL4160111 | — | — | 1 | 6.66 |
| CHEMBL4174176 | — | — | 1 | 6.62 |
| CHEMBL4169598 | — | — | 1 | 5.89 |
| CHEMBL4167587 | — | — | 1 | 5.74 |
| CHEMBL4162406 | — | — | 1 | 5.48 |
| CHEMBL4165760 | — | — | 1 | - |
| CHEMBL4172992 | — | — | 1 | - |
| CHEMBL3770000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161444 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4176554 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4162499 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4169762 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4159112 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4165937 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4169368 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4170327 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4162316 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4164687 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4172576 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4170753 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4177454 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4161265 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3414621 | TAZEMETOSTAT | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4176373 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4169191 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4160111 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4174176 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4169598 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4167587 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4162406 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4165760 | — | IC50 | - | — | - | |
| CHEMBL4172992 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3770000 | — | IC50 | - | — | - |