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Assay Detail

CHEMBL4145012

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rabbit IDO using tryptophan as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold.
Brant MG, Goodwin-Tindall J, Stover KR, Stafford PM, Wu F, Meek AR, Schiavini P, Wohnig S, Weaver DF.
ACS Med Chem Lett (2018) 9 : 131 -136
PubMed 29456801 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.50 4.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4169249 1 4.52
CHEMBL504816 (L)-1-METHYLTRYPTOPHAN 1 4.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4169249 IC50 = 30500.0 nM 4.52
CHEMBL504816 (L)-1-METHYLTRYPTOPHAN IC50 = 34000.0 nM 4.47