Assay Detail
Binding
CHEMBL4145113
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Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.50 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4174691 | — | — | 1 | 8.77 |
| CHEMBL4167532 | — | — | 1 | 8.24 |
| CHEMBL4170908 | — | — | 1 | 8.22 |
| CHEMBL4175397 | — | — | 1 | 8.15 |
| CHEMBL4159562 | — | — | 1 | 8.13 |
| CHEMBL4167473 | — | — | 1 | 7.66 |
| CHEMBL4160295 | — | — | 1 | 7.63 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL4174345 | — | — | 1 | 7.32 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL4162920 | — | — | 1 | 7.27 |
| CHEMBL4162590 | — | — | 1 | 7.23 |
| CHEMBL4170860 | — | — | 1 | 7.21 |
| CHEMBL4166379 | — | — | 1 | 7.13 |
| CHEMBL4174295 | — | — | 1 | 7.08 |
| CHEMBL4170519 | — | — | 1 | 7.07 |
| CHEMBL4170536 | — | — | 1 | 7.03 |
| CHEMBL4161638 | — | — | 1 | 7.02 |
| CHEMBL4163665 | — | — | 1 | 6.97 |
| CHEMBL4173735 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4174691 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4167532 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL4170908 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4175397 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4159562 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL4167473 | — | Ki | = | 22.1 | nM | 7.66 |
| CHEMBL4160295 | — | Ki | = | 23.4 | nM | 7.63 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4174345 | — | Ki | = | 47.6 | nM | 7.32 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL4162920 | — | Ki | = | 53.6 | nM | 7.27 |
| CHEMBL4162590 | — | Ki | = | 59.2 | nM | 7.23 |
| CHEMBL4170860 | — | Ki | = | 61.8 | nM | 7.21 |
| CHEMBL4166379 | — | Ki | = | 74.7 | nM | 7.13 |
| CHEMBL4174295 | — | Ki | = | 83.1 | nM | 7.08 |
| CHEMBL4170519 | — | Ki | = | 84.6 | nM | 7.07 |
| CHEMBL4170536 | — | Ki | = | 93.1 | nM | 7.03 |
| CHEMBL4161638 | — | Ki | = | 95.4 | nM | 7.02 |
| CHEMBL4163665 | — | Ki | = | 107.7 | nM | 6.97 |
| CHEMBL4173735 | — | Ki | = | 126.5 | nM | 6.90 |