Assay Detail
Binding
CHEMBL4145136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of protease L10F/V32I/M46I/I47V/Q58E/I84V mutant in HIV1 A17 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.59 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173216 | — | — | 1 | 7.60 |
| CHEMBL4164025 | — | — | 1 | 7.21 |
| CHEMBL4160695 | — | — | 1 | 7.08 |
| CHEMBL4163344 | — | — | 1 | 7.02 |
| CHEMBL4168317 | — | — | 1 | 6.78 |
| CHEMBL4160405 | — | — | 1 | 6.65 |
| CHEMBL4165197 | — | — | 1 | 6.51 |
| CHEMBL4159139 | — | — | 1 | 6.17 |
| CHEMBL4160986 | — | — | 1 | 5.96 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 5.94 |
| CHEMBL300891 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173216 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4164025 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4160695 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4163344 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4168317 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL4160405 | — | EC50 | = | 226.0 | nM | 6.65 |
| CHEMBL4165197 | — | EC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4159139 | — | EC50 | = | 678.0 | nM | 6.17 |
| CHEMBL4160986 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL300891 | — | EC50 | = | 2730.0 | nM | 5.56 |