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Assay Detail

CHEMBL4145238

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Functional
Antiviral activity against Hepatitis B virus infected in human HepG2.117 cells assessed as inhibition of viral DNA level after 3 days by real time PCR
ChEMBL ↗
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepatitis B virus
Confidence 1 — Organism
Curated By Intermediate

Target

Hepatitis B virus (CHEMBL613497) ↗
Type ORGANISM
Organism Hepatitis B virus

Publication

Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV).
Vandyck K, Rombouts G, Stoops B, Tahri A, Vos A, Verschueren W, Wu Y, Yang J, Hou F, Huang B, Vergauwen K, Dehertogh P, Berke JM, Raboisson P.
J Med Chem (2018) 61 : 6247 -6260
PubMed 29906396 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 61 5.71 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4163671 — — 1 6.82
CHEMBL4170099 — — 1 6.52
CHEMBL4170274 — — 1 6.44
CHEMBL4173963 — — 1 6.40
CHEMBL4166873 — — 1 6.38
CHEMBL4163019 — — 1 6.37
CHEMBL4159471 — — 1 6.37
CHEMBL4174998 — — 1 6.29
CHEMBL4166338 — — 1 6.24
CHEMBL4160850 — — 1 6.22
CHEMBL4174246 — — 1 6.22
CHEMBL4166164 — — 1 6.18
CHEMBL4167378 — — 1 6.11
CHEMBL4159644 — — 1 6.11
CHEMBL4163010 — — 1 6.05
CHEMBL4171311 — — 1 6.05
CHEMBL4170524 — — 1 6.04
CHEMBL4162833 — — 1 6.03
CHEMBL4161956 — — 1 6.02
CHEMBL4167121 — — 1 6.01
CHEMBL4161261 — — 1 5.92
CHEMBL4171468 — — 1 5.89
CHEMBL4166289 — — 1 5.87
CHEMBL4174774 — — 1 5.82
CHEMBL4162188 — — 1 5.78
CHEMBL4163941 — — 1 5.78
CHEMBL4174338 — — 1 5.72
CHEMBL4165879 — — 1 5.72
CHEMBL4170775 — — 1 5.69
CHEMBL4169186 — — 1 5.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4163671 — EC50 = 150.0 nM 6.82
CHEMBL4170099 — EC50 = 300.0 nM 6.52
CHEMBL4170274 — EC50 = 360.0 nM 6.44
CHEMBL4173963 — EC50 = 400.0 nM 6.40
CHEMBL4166873 — EC50 = 420.0 nM 6.38
CHEMBL4163019 — EC50 = 430.0 nM 6.37
CHEMBL4159471 — EC50 = 430.0 nM 6.37
CHEMBL4174998 — EC50 = 510.0 nM 6.29
CHEMBL4166338 — EC50 = 580.0 nM 6.24
CHEMBL4160850 — EC50 = 600.0 nM 6.22
CHEMBL4174246 — EC50 = 600.0 nM 6.22
CHEMBL4166164 — EC50 = 660.0 nM 6.18
CHEMBL4159644 — EC50 = 780.0 nM 6.11
CHEMBL4167378 — EC50 = 780.0 nM 6.11
CHEMBL4171311 — EC50 = 900.0 nM 6.05
CHEMBL4163010 — EC50 = 890.0 nM 6.05
CHEMBL4170524 — EC50 = 910.0 nM 6.04
CHEMBL4162833 — EC50 = 930.0 nM 6.03
CHEMBL4161956 — EC50 = 960.0 nM 6.02
CHEMBL4167121 — EC50 = 980.0 nM 6.01
CHEMBL4161261 — EC50 = 1200.0 nM 5.92
CHEMBL4171468 — EC50 = 1300.0 nM 5.89
CHEMBL4166289 — EC50 = 1360.0 nM 5.87
CHEMBL4174774 — EC50 = 1510.0 nM 5.82
CHEMBL4163941 — EC50 = 1670.0 nM 5.78
CHEMBL4162188 — EC50 = 1650.0 nM 5.78
CHEMBL4174338 — EC50 = 1910.0 nM 5.72
CHEMBL4165879 — EC50 = 1910.0 nM 5.72
CHEMBL4170775 — EC50 = 2030.0 nM 5.69
CHEMBL4169186 — EC50 = 2200.0 nM 5.66
CHEMBL4173717 — EC50 = 2280.0 nM 5.64
CHEMBL4166173 — EC50 = 2590.0 nM 5.59
CHEMBL4171559 — EC50 = 2660.0 nM 5.58
CHEMBL4171318 — EC50 = 2700.0 nM 5.57
CHEMBL4159872 — EC50 = 2790.0 nM 5.55
CHEMBL4177085 — EC50 = 3030.0 nM 5.52
CHEMBL4163416 — EC50 = 3050.0 nM 5.52
CHEMBL4169882 — EC50 = 2990.0 nM 5.52
CHEMBL4176489 — EC50 = 3300.0 nM 5.48
CHEMBL4159641 — EC50 = 3630.0 nM 5.44
CHEMBL4174201 — EC50 = 4680.0 nM 5.33
CHEMBL4167984 — EC50 = 6300.0 nM 5.20
CHEMBL4170270 — EC50 = 8630.0 nM 5.06
CHEMBL4160057 — EC50 = 11100.0 nM 4.96
CHEMBL4166460 — EC50 = 11000.0 nM 4.96
CHEMBL4164684 — EC50 = 11100.0 nM 4.96
CHEMBL4163422 — EC50 = 15300.0 nM 4.82
CHEMBL4174590 — EC50 = 16000.0 nM 4.80
CHEMBL4167584 — EC50 = 16290.0 nM 4.79
CHEMBL4172572 — EC50 = 16300.0 nM 4.79