Assay Detail
Functional
CHEMBL4145344
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Antiviral activity against DENV2 New Guinea C infected in human HuH7 cells after 48 hrs by luciferase reporter gene assay
42
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC90 | 21 | - | - |
| EC50 | 21 | 5.75 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4159403 | — | — | 2 | 6.75 |
| CHEMBL4169166 | — | — | 2 | 6.33 |
| CHEMBL4165336 | — | — | 2 | 6.16 |
| CHEMBL4159994 | — | — | 2 | 6.12 |
| CHEMBL4172550 | — | — | 2 | 6.09 |
| CHEMBL4177020 | — | — | 2 | 6.08 |
| CHEMBL4174075 | — | — | 2 | 5.96 |
| CHEMBL3425867 | — | — | 2 | 5.73 |
| CHEMBL4167255 | — | — | 2 | 5.70 |
| CHEMBL4163357 | — | — | 2 | 5.68 |
| CHEMBL4170643 | — | — | 2 | 5.56 |
| CHEMBL4171678 | — | — | 2 | 5.39 |
| CHEMBL4168337 | — | — | 2 | 5.28 |
| CHEMBL4160425 | — | — | 2 | 5.28 |
| CHEMBL4166209 | — | — | 2 | 5.24 |
| CHEMBL4162766 | — | — | 2 | 5.20 |
| CHEMBL4175117 | — | — | 2 | 5.15 |
| CHEMBL4163801 | — | — | 2 | - |
| CHEMBL4167311 | — | — | 2 | - |
| CHEMBL4170698 | — | — | 2 | - |
| CHEMBL4161901 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4159403 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4169166 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4165336 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4159994 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4172550 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4177020 | — | EC50 | = | 841.6 | nM | 6.08 |
| CHEMBL4174075 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3425867 | — | EC50 | = | 1844.0 | nM | 5.73 |
| CHEMBL4167255 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4163357 | — | EC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL4170643 | — | EC50 | = | 2735.0 | nM | 5.56 |
| CHEMBL4171678 | — | EC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4168337 | — | EC50 | = | 5305.0 | nM | 5.28 |
| CHEMBL4160425 | — | EC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL4166209 | — | EC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL4162766 | — | EC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL4175117 | — | EC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL4163357 | — | EC90 | = | 6.5 | uM | - |
| CHEMBL4161901 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4174075 | — | EC90 | = | 2.9 | uM | - |
| CHEMBL4159994 | — | EC90 | = | 2.74 | uM | - |
| CHEMBL3425867 | — | EC90 | = | 8.05 | uM | - |
| CHEMBL4166209 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4170698 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4170643 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4167311 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4159403 | — | EC90 | = | 0.56 | uM | - |
| CHEMBL4160425 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4168337 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4163801 | — | EC90 | > | 20.0 | uM | - |
| CHEMBL4171678 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4167255 | — | EC90 | = | 4.15 | uM | - |
| CHEMBL4175117 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4162766 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4161901 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4169166 | — | EC90 | = | 1.34 | uM | - |
| CHEMBL4165336 | — | EC90 | = | 2.15 | uM | - |
| CHEMBL4170698 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4163801 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4177020 | — | EC90 | = | 3.92 | uM | - |
| CHEMBL4167311 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4172550 | — | EC90 | = | 1.76 | uM | - |