Assay Detail
Binding
CHEMBL4146155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate by fluorescence method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.57 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526243 | — | — | 1 | 8.17 |
| CHEMBL526013 | — | — | 1 | 8.12 |
| CHEMBL531405 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526243 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL526013 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL531405 | — | IC50 | = | 382.1 | nM | 6.42 |