Assay Detail
Functional
CHEMBL4146208
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Antiproliferative activity against human NCI-H3122 cells after 72 hrs by SRB or CCK8 assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H3122 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 2,4-diarylaminopyrimidines bearing a resorcinol motif as novel ALK inhibitors to overcome the G1202R resistant mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.47 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168049 | — | — | 1 | 8.40 |
| CHEMBL4172925 | — | — | 1 | 8.17 |
| CHEMBL4168868 | — | — | 1 | 8.16 |
| CHEMBL4177038 | — | — | 1 | 8.14 |
| CHEMBL3286830 | LORLATINIB | 4.0 | 1 | 8.11 |
| CHEMBL4175908 | — | — | 1 | 8.04 |
| CHEMBL4162661 | — | — | 1 | 7.89 |
| CHEMBL4170592 | — | — | 1 | 7.86 |
| CHEMBL4174031 | — | — | 1 | 7.24 |
| CHEMBL4168701 | — | — | 1 | 7.19 |
| CHEMBL4170213 | — | — | 1 | 7.16 |
| CHEMBL4162295 | — | — | 1 | 7.08 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 7.02 |
| CHEMBL3357439 | — | — | 1 | 7.01 |
| CHEMBL4172048 | — | — | 1 | 7.00 |
| CHEMBL4176561 | — | — | 1 | 6.91 |
| CHEMBL4169529 | — | — | 1 | 6.59 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.52 |
| CHEMBL4166111 | — | — | 1 | - |
| CHEMBL4177392 | — | — | 1 | - |
| CHEMBL4162252 | — | — | 1 | - |
| CHEMBL4161453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168049 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4172925 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4168868 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4177038 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3286830 | LORLATINIB | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4175908 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4162661 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL4170592 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL4174031 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4168701 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4170213 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4162295 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3357439 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4172048 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4176561 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL4169529 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL4166111 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4177392 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4162252 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4161453 | — | IC50 | > | 1000.0 | nM | - |