Assay Detail
Binding
CHEMBL4146374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Ketanserin from human 5HT2AR expressed in CHO-K1 cell membranes after 1.5 hrs by microbeta counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.55 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1083390 | INTEPIRDINE | 3.0 | 1 | 7.58 |
| CHEMBL4175829 | — | — | 1 | 6.36 |
| CHEMBL4164541 | — | — | 1 | 6.35 |
| CHEMBL4169236 | — | — | 1 | 6.32 |
| CHEMBL4161308 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1083390 | INTEPIRDINE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4175829 | — | Ki | = | 441.0 | nM | 6.36 |
| CHEMBL4164541 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL4169236 | — | Ki | = | 475.0 | nM | 6.32 |
| CHEMBL4161308 | — | Ki | = | 694.0 | nM | 6.16 |