Assay Detail
Binding
CHEMBL4146403
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Binding affinity to 5HT6R (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.06 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170220 | — | — | 1 | 9.70 |
| CHEMBL1083390 | INTEPIRDINE | 3.0 | 1 | 9.55 |
| CHEMBL4169827 | — | — | 1 | 9.52 |
| CHEMBL3286580 | IDALOPIRDINE | 3.0 | 1 | 9.08 |
| CHEMBL370779 | — | — | 1 | 9.00 |
| CHEMBL4161904 | — | — | 1 | 8.30 |
| CHEMBL4177024 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170220 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1083390 | INTEPIRDINE | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL4169827 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3286580 | IDALOPIRDINE | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL370779 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4161904 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4177024 | — | Ki | = | 5.0 | nM | 8.30 |