Assay Detail
Functional
CHEMBL4146454
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Cytotoxicity against human HT-29 cells after 72 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New insights into structure-activity relationship of ipomoeassin F from its bioisosteric 5-oxa/aza analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.29 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163767 | — | — | 1 | 8.38 |
| CHEMBL502784 | IPOMOEASSIN D | — | 1 | 7.93 |
| CHEMBL506305 | IPOMOEASSIN A | — | 1 | 7.34 |
| CHEMBL443118 | IPOMOEASSIN E | — | 1 | 6.41 |
| CHEMBL454218 | IPOMOEASSIN B | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163767 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL502784 | IPOMOEASSIN D | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL506305 | IPOMOEASSIN A | IC50 | = | 46.1 | nM | 7.34 |
| CHEMBL443118 | IPOMOEASSIN E | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL454218 | IPOMOEASSIN B | IC50 | = | 396.0 | nM | 6.40 |