Assay Detail
Functional
CHEMBL4146459
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by Alamar Blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New insights into structure-activity relationship of ipomoeassin F from its bioisosteric 5-oxa/aza analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.14 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163767 | — | — | 1 | 8.11 |
| CHEMBL4175499 | — | — | 1 | 7.84 |
| CHEMBL4161457 | — | — | 1 | 7.50 |
| CHEMBL4172051 | — | — | 1 | 7.31 |
| CHEMBL4163331 | — | — | 1 | 7.17 |
| CHEMBL4161019 | — | — | 1 | 6.58 |
| CHEMBL4168944 | — | — | 1 | 6.54 |
| CHEMBL4174044 | — | — | 1 | 6.09 |
| CHEMBL4164873 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163767 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4175499 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4161457 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL4172051 | — | IC50 | = | 48.7 | nM | 7.31 |
| CHEMBL4163331 | — | IC50 | = | 68.3 | nM | 7.17 |
| CHEMBL4161019 | — | IC50 | = | 259.9 | nM | 6.58 |
| CHEMBL4168944 | — | IC50 | = | 290.3 | nM | 6.54 |
| CHEMBL4174044 | — | IC50 | = | 808.5 | nM | 6.09 |
| CHEMBL4164873 | — | IC50 | > | 25000.0 | nM | - |