Assay Detail
Binding
CHEMBL4146867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus Newman 6His-tagged CrtN expressed in Escherichia coli BL21(DE3) assessed as 4,4'-diapophytoene accumulation by Western blot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus subsp. aureus str. Newman |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) (CHEMBL3813586) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain Newman) |
Publication
Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.38 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4162120 | — | — | 1 | 6.39 |
| CHEMBL4161555 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4162120 | — | IC50 | = | 407.8 | nM | 6.39 |
| CHEMBL4161555 | — | IC50 | = | 430.0 | nM | 6.37 |